p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets.

Product information

CAS Number: 1095003-80-7

Molecular Weight: 475.58

Formula: C27H33N5O3

Chemical Name: N-cyclopropyl-4-methyl-3-{3-[(2-{2-[2-(methylamino)ethoxy]phenyl}propan-2-yl)amino]-2-oxo-1,2-dihydropyrazin-1-yl}benzamide

Smiles: CC1=CC=C(C=C1N1C=CN=C(NC(C)(C)C2=CC=CC=C2OCCNC)C1=O)C(=O)NC1CC1

InChiKey: SAZVRXTVWZAHBI-UHFFFAOYSA-N

InChi: InChI=1S/C27H33N5O3/c1-18-9-10-19(25(33)30-20-11-12-20)17-22(18)32-15-13-29-24(26(32)34)31-27(2,3)21-7-5-6-8-23(21)35-16-14-28-4/h5-10,13,15,17,20,28H,11-12,14,16H2,1-4H3,(H,29,31)(H,30,33)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (525.67 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.