Cdc6 (phospho Ser54) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8123-50, ES8123-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008],

Alternate Name: CDC6; CDC18L; Cell division control protein 6 homolog; CDC6-related protein; Cdc18-related protein; HsCdc18; p62 (cdc6); HsCDC6

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse; Monkey

Immunogen: The antiserum was produced against synthesized peptide derived from human CDC6 around the phosphorylation site of Ser54. AA range:20-69

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 62kD

Human Gene ID: 990

Human SWISS Prot NO: Q99741

Subcellular Location: Nucleus. Cytoplasm. The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895).

Research Use Only